African sleeping sickness, Chagas disease and leishmaniasis are potential lethal human and cattle diseases caused by kinetoplastids Trypanosoma brucei, cruzi and Leishmania respectively, which belong to a group of unicellular eukaryotic parasites. There is an urgent need for discovery of novel, more effective and safer drugs against these neglected tropical diseases. We chose to target ribosome translation machinery, one of the most essential machineries for the parasite survival. Ribosome is a hybrid RNA-protein complex that is responsible for the translation of mRNA, a pivotal step in cell protein synthesis. We endeavor to assess the druggability of the parasite-specific sites in this complex that could serve as potential targets for safer and more efficient therapeutic drugs.