Welcome to the Hashem Lab

Our research is focused on mRNA translation in eukaryotic pathogens and their hosts. We endeavor to understand the regulation of the translation process and decipher structurally, using CryoEM-electron microscopy (cryo-EM), its molecular basis and most importantly, the differences between eukaryotic pathogens and their mammalian hosts.

translation in mammals

mRNA translation in mammals with a particular focus on the structural differences compared to parasites

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translation in parasites

mRNA translation in trypanosomatides and kinetoplastids with a focus on the initiation step and its unique features

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translation in mitochondria

mRNA translation in mitochondria in both pathogenic parasites and their mammalian hosts

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About the lab

We are part of the ARNA unit (Nucleic Acids: Natural and Artificial Regulation),
Inserm U1212 – CNRS UMR 5320 and we are affiliated the University of Bordeaux.
We are located at the European Institute of Chemistry and Biology (IECB) in the city of Bordeaux, France.

Last Tweets

Yaser Hashem
@Hashemyaser4Jul 24
My first in-person meeting in 20 months 🤓 Go @ebsa_in !! https://t.co/sefzBt6IyO
Yaser Hashem
@Hashemyaser4Jul 24
RT @WilsonLab2: Our paper is out on the Structural and mechanistic basis for translation inhibition by macrolide and ketolide antibiotics.…
Yaser Hashem
@Hashemyaser4Jul 23
RT @GrailleLab: Fun, impressive and amazing. We just solved a structure, which was reluctant to phasing (no good enough model for molecular…
Yaser Hashem
@Hashemyaser4Jul 23
RT @LugerLab: Our paper with @chantal_abergel is finally out. fabulous collaboration and great teamwork between so many talented people i…
Yaser Hashem
@Hashemyaser4Jul 22
Yaser Hashem
@Hashemyaser4Jul 21
RT @BolandLab_GE: 📢Very happy to share the first publication of our lab at UNIGE @unige_en published in Nature @Nature. This has been a hi…
Yaser Hashem
@Hashemyaser4Jul 20
Yaser Hashem
@Hashemyaser4Jul 20
@paul_lesbats @AgenceRecherche @cnrs_ibmp @GiegeP Thanks 🙏🙏 I'm afraid Bugs Bunny has way more 💶💶💶 than we do 😅
Yaser Hashem
@Hashemyaser4Jul 20
Great SRP story by the @The_Ban_Lab piloted by @a__jomaa https://t.co/BziuoD0iCT
Yaser Hashem
@Hashemyaser4Jul 20
YOUPI! our project ARAMIS poised at studying translation regulation in chlamydomonas reinhardtii mitochondrial mRNA… https://t.co/D7duj3l7Qa