Welcome to the Hashem Lab

Our research is focused on mRNA translation in eukaryotic pathogens and their hosts. We endeavor to understand the regulation of the translation process and decipher structurally, using CryoEM-electron microscopy (cryo-EM), its molecular basis and most importantly, the differences between eukaryotic pathogens and their mammalian hosts.

translation in mammals

mRNA translation in mammals with a particular focus on the structural differences compared to parasites

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translation in parasites

mRNA translation in trypanosomatides and kinetoplastids with a focus on the initiation step and its unique features

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translation in mitochondria

mRNA translation in mitochondria in both pathogenic parasites and their mammalian hosts

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About the lab

We are part of the ARNA unit (Nucleic Acids: Natural and Artificial Regulation),
Inserm U1212 – CNRS UMR 5320 and we are affiliated the University of Bordeaux.
We are located at the European Institute of Chemistry and Biology (IECB) in the city of Bordeaux, France.

Last Tweets

Yaser Hashem
@Hashemyaser4Jan 22
RT @GilbertLabRNA: More good news! 🎉 Here we uncover roles for pseudouridylation and pseudouridine syntheses in alternative mRNA processing…
Yaser Hashem
@Hashemyaser4Jan 19
RT @TeaLenarcic: Honored to be a part of this long-lasting colab between @aschneiderlab and @The_Ban_Lab. Cheers to everybody involved!
Yaser Hashem
@Hashemyaser4Jan 19
RT @aschneiderlab: T. brucei mitoribosomes continue to surprise. Assembly of the SSU involves a non-canonical role of IF2. - Another great…
Yaser Hashem
@Hashemyaser4Jan 19
RT @ScottDuncanWX: 142 years of climate change in 15 seconds https://t.co/cLm3jDHJEd
Yaser Hashem
@Hashemyaser4Jan 19
@IsraelF96135088 Looks a lot like the USS Entrprise warp reactor engin room https://t.co/PgN58i62E8
Yaser Hashem
@Hashemyaser4Jan 19
RT @arna_lab: We are very excited to announce the first series of on-line seminars organized for the SifrARN community! First seminar, with…
Yaser Hashem
@Hashemyaser4Jan 18
RT @joachimfrank: I need a lot of sheep to voice my opinion
Yaser Hashem
@Hashemyaser4Jan 17
RT @bengeliscious: 📢The @biozentrum BioEM Facility is looking for a new #CryoET specialist. My group will work closely with this person to…
Yaser Hashem
@Hashemyaser4Jan 12
RT @EWB_Lab: Check out our structural study on engagement and translocation of pupylated substrate into the Mpa  #proteasome from #Mycobact…
Yaser Hashem
@Hashemyaser4Jan 11
RT @RubinsteinJohn: We will soon advertise a new scientific staff position for our cryoEM Core facility. It's not clear to me if there are…