Welcome to the Hashem Lab

Our research is focused on mRNA translation in eukaryotic pathogens and their hosts. We endeavor to understand the regulation of the translation process and decipher structurally, using CryoEM-electron microscopy (cryo-EM), its molecular basis and most importantly, the differences between eukaryotic pathogens and their mammalian hosts.

translation in mammals

mRNA translation in mammals with a particular focus on the structural differences compared to parasites

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translation in parasites

mRNA translation in trypanosomatides and kinetoplastids with a focus on the initiation step and its unique features

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translation in mitochondria

mRNA translation in mitochondria in both pathogenic parasites and their mammalian hosts

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About the lab

We are part of the ARNA unit (Nucleic Acids: Natural and Artificial Regulation),
Inserm U1212 – CNRS UMR 5320 and we are affiliated the University of Bordeaux.
We are located at the European Institute of Chemistry and Biology (IECB) in the city of Bordeaux, France.

Last Tweets

Yaser Hashem
@Hashemyaser4Nov 26
RT @chillzaa: New ribosome structure from cold-adapted bacterium reveals a translation factor structurally similar to eRF1 and Pelota bound…
Yaser Hashem
@Hashemyaser4Nov 25
RT @PMorgaDavid: New paper in collaboration with Guy Caljon's group from Antwerp University. We show that Trypanosoma brucei parasites rapi…
Yaser Hashem
@Hashemyaser4Nov 24
RT @DmitriErmolenko: Our work showing that base pair formation by the 3' UTR can enhance cap-poly(A) synergy in eukaryotic translation is o…
Yaser Hashem
@Hashemyaser4Nov 24
@jomaa_lab Looks like you're 2nm away for forming a crystal 🤓
Yaser Hashem
@Hashemyaser4Nov 23
RT @RouslanEfremov: Time-resolved cryo-EM reveals early ribosome assembly in action https://t.co/jrll1tRGz8
Yaser Hashem
@Hashemyaser4Nov 23
RT @LanderLab: Now accepting applications for the 2023 Cryo-EM course at Cold Spring Harbor Lab @CSHL - 2 weeks of hands-on training in sam…
Yaser Hashem
@Hashemyaser4Nov 17
RT @WilsonLab2: Our paper is out on the Structure of Escherichia coli heat shock protein Hsp15 in complex with the ribosomal 50S subunit be…
Yaser Hashem
@Hashemyaser4Nov 16
@yo_arfi Hahaha 🤓 but I already have joined 😉
Yaser Hashem
@Hashemyaser4Nov 16
Crazy organisms! Not only their ribosomes are reduced, but also their proteasomes🤯🤯! What else?!🤔 https://t.co/XkzJ40xoXP
Yaser Hashem
@Hashemyaser4Nov 14
RT @krastevalab: Please RT: A post-doctoral and/or staff scientist position(s) available in my lab on the structural biology of c-di-GMP-de…