Welcome to the Hashem Lab

Our research is focused on mRNA translation in eukaryotic pathogens and their hosts. We endeavor to understand the regulation of the translation process and decipher structurally, using CryoEM-electron microscopy (cryo-EM), its molecular basis and most importantly, the differences between eukaryotic pathogens and their mammalian hosts.

translation in mammals

mRNA translation in mammals with a particular focus on the structural differences compared to parasites

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translation in parasites

mRNA translation in trypanosomatides and kinetoplastids with a focus on the initiation step and its unique features

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translation in mitochondria

mRNA translation in mitochondria in both pathogenic parasites and their mammalian hosts

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About the lab

We are part of the ARNA unit (Nucleic Acids: Natural and Artificial Regulation),
Inserm U1212 – CNRS UMR 5320 and we are affiliated the University of Bordeaux.
We are located at the European Institute of Chemistry and Biology (IECB) in the city of Bordeaux, France.

Last Tweets

Yaser Hashem
@Hashemyaser4Aug 12
RT @bengeliscious: We are excited to share our new preprint on the structure and function VIPP1, a conserved membrane-remodeling protein re…
Yaser Hashem
@Hashemyaser4Aug 12
RT @cryoEM_Papers: The In Situ Structure of Parkinson’s Disease-Linked LRRK2 https://t.co/DgCppPFmWZ
Yaser Hashem
@Hashemyaser4Aug 11
RT @cryoEM_Papers: Time-resolved cryo-EM using Spotiton https://t.co/S23owMHsfM
Yaser Hashem
@Hashemyaser4Aug 09
@InnisLab @IsraelF96135088 Ah c'mon don't be sad, for all what it's worth, it is the hottest part of the ribosome 🤓
Yaser Hashem
@Hashemyaser4Aug 09
@IsraelF96135088 @InnisLab 🤣 that must be the peptide tunnel
Yaser Hashem
@Hashemyaser4Aug 09
@InnisLab After foot and toe printing, finger printing, I wonder what would be the next "printing"...🤔
Yaser Hashem
@Hashemyaser4Aug 08
RT @RadoDanev: An update about the #KriosG4 test dataset. It reached 1.33 Å with 180k particles. This was quite a nice surprise.🙂 I thought…
Yaser Hashem
@Hashemyaser4Aug 07
RT @cryoEM_Papers: Structural analysis of full-length SARS-CoV-2 spike protein from an advanced vaccine candidate https://t.co/4X6jKOhrzC
Yaser Hashem
@Hashemyaser4Aug 07
RT @RubinsteinJohn: Mycobacteria can survive low-energy conditions, allowing latent, antibiotic resistant, TB infections to persist for dec…
Yaser Hashem
@Hashemyaser4Aug 04
RT @GreenLabJHMI: Check out the latest quarantine collab with @BeckmannLab @jwadeharper1 and @ebennettlab .... EDF1 coordinates major cellu…