Welcome to the Hashem Lab

Our research is focused on mRNA translation in eukaryotic pathogens and their hosts. We endeavor to understand the regulation of the translation process and decipher structurally, using CryoEM-electron microscopy (cryo-EM), its molecular basis and most importantly, the differences between eukaryotic pathogens and their mammalian hosts.

translation in mammals

mRNA translation in mammals with a particular focus on the structural differences compared to parasites

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translation in parasites

mRNA translation in trypanosomatides and kinetoplastids with a focus on the initiation step and its unique features

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translation in mitochondria

mRNA translation in mitochondria in both pathogenic parasites and their mammalian hosts

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About the lab

We are part of the ARNA unit (Nucleic Acids: Natural and Artificial Regulation),
Inserm U1212 – CNRS UMR 5320 and we are affiliated the University of Bordeaux.
We are located at the European Institute of Chemistry and Biology (IECB) in the city of Bordeaux, France.

Last Tweets

Yaser Hashem
@Hashemyaser4Aug 07
@FlorentWaltz @snsf_ch Congrats guys 🤘🤓
Yaser Hashem
@Hashemyaser4Aug 05
RT @kellogg_liz: 🔥hot off the press from the @kellogg_liz lab 🔥 We report the first cryo-EM structure of a CAST catalytic component, common…
Yaser Hashem
@Hashemyaser4Aug 05
RT @IsraelF96135088: WOW! drop everything you are doing! 👇👇👇 TnsB structure of the V-K CAST system visualized with DNA!!! Wonder-cryo-Wo…
Yaser Hashem
@Hashemyaser4Jul 30
RT @jomaa_lab: Postdoc position is now posted, if interested please apply at: https://t.co/wLMxDVeTw1, application review starts August 23r…
Yaser Hashem
@Hashemyaser4Jul 28
RT @MiriKrupkin: Excited to share our paper on designing a #specialproportions long #variablearm #tRNA to fit & function in the #ribosome!🧬…
Yaser Hashem
@Hashemyaser4Jul 27
RT @cziscience: We’re excited to announce that David Agard, Bridget Carragher + Clint Potter have joined our new @ChanZuckerberg Imaging In…
Yaser Hashem
@Hashemyaser4Jul 22
RT @cdmackereth: Sébastien @Seb_Campagne joined us last year in Bordeaux as a new @Inserm researcher @arna_lab, and this review (as corresp…
Yaser Hashem
@Hashemyaser4Jul 21
@N__Fischer @2022Ribosomes @InnisLab @IgnatovaLab I was such a pleasure to host you Niels and hear about this amazing story!
Yaser Hashem
@Hashemyaser4Jul 20
@nevacaliskan OK they will now 😁
Yaser Hashem
@Hashemyaser4Jul 19