Welcome to the Hashem Lab

Our research is focused on mRNA translation in eukaryotic pathogens and their hosts. We endeavor to understand the regulation of the translation process and decipher structurally, using CryoEM-electron microscopy (cryo-EM), its molecular basis and most importantly, the differences between eukaryotic pathogens and their mammalian hosts.

translation in mammals

mRNA translation in mammals with a particular focus on the structural differences compared to parasites

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translation in parasites

mRNA translation in trypanosomatides and kinetoplastids with a focus on the initiation step and its unique features

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translation in mitochondria

mRNA translation in mitochondria in both pathogenic parasites and their mammalian hosts

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About the lab

We are part of the ARNA unit (Nucleic Acids: Natural and Artificial Regulation),
Inserm U1212 – CNRS UMR 5320 and we are affiliated the University of Bordeaux.
We are located at the European Institute of Chemistry and Biology (IECB) in the city of Bordeaux, France.

Last Tweets

Yaser Hashem
@Hashemyaser4Oct 02
RT @KorostelevLab: How do Dicer-1 and Loqs-PB make miRNA? We captured 6 cryo-EM structures showing stages of pre-miRNA cleavage. Dicer•Loq…
Yaser Hashem
@Hashemyaser4Sep 30
RT @Liang_Xue_: Glad to share our new paper on exploring the limits of cryo-ET. We elucidate how the translation machinery in a simple bact…
Yaser Hashem
@Hashemyaser4Sep 25
RT @zfreyberg: Amazing work by @Neuro_Jenesis in conjunction with @dr_monga77, Monga lab, @StefPuig offering the first comprehensive spatia…
Yaser Hashem
@Hashemyaser4Sep 24
@waldeyr @JessCruz31 @raquelminardi @GisCurty It was great being there! Thank you so much for the hospitality
Yaser Hashem
@Hashemyaser4Sep 24
Heading back from the BSB 2022 in the beautiful city of Búzios (Brazil), so happy to return to my beloved ones, but… https://t.co/5Lq4az5qVr
Yaser Hashem
@Hashemyaser4Sep 24
le sentiment est fortement partagé @fronzes_lab 😖 https://t.co/jEZcoZuQBR
Yaser Hashem
@Hashemyaser4Sep 22
RT @woodson_lab: Registration is now open for the 2023 GRC @GordonConf on RNA Nanotechnology! We have a fantastic line-up of speakers on RN…
Yaser Hashem
@Hashemyaser4Sep 22
@IgnatovaLab Haha it's a bit creepy I have to confess 🙈
Yaser Hashem
@Hashemyaser4Sep 21
Still rocking at the BSB 2022 meeting in Búzios 😎 some history: My new friends explained to me the touristic histor… https://t.co/517OwwRw28
Yaser Hashem
@Hashemyaser4Sep 21