THE HASHEM LAB

New papers
Structural Insights into the Mammalian Late-Stage Initiation Complexes (2020). Cell Reports 31, 107497.

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Translation in Mitochondria

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New papers
Cryo-EM structure of the RNA-rich plant mitochondrial ribosome (Nature plants, 2020)

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New papers
Specific features and assembly of the plant mitochondrial complex I revealed by cryo-EM

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Welcome to the Hashem Lab

Our research is focused on mRNA translation in eukaryotic pathogens and their hosts. We endeavor to understand the regulation of the translation process and decipher structurally, using CryoEM-electron microscopy (cryo-EM), its molecular basis and most importantly, the differences between eukaryotic pathogens and their mammalian hosts.

translation in mammals

mRNA translation in mammals with a particular focus on the structural differences compared to parasites

translation in parasites

mRNA translation in trypanosomatides and kinetoplastids with a focus on the initiation step and its unique features

translation in mitochondria

mRNA translation in mitochondria in both pathogenic parasites and their mammalian hosts

We are part of the ARNA unit (Nucleic Acids: Natural and Artificial Regulation),
Inserm U1212 – CNRS UMR 5320 and we are affiliated the University of Bordeaux.

We are located at the European Institute of Chemistry and Biology (IECB) in the city of Bordeaux, France.

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