Welcome to the Hashem Lab

Our research is focused on mRNA translation in eukaryotic pathogens and their hosts. We endeavor to understand the regulation of the translation process and decipher structurally, using CryoEM-electron microscopy (cryo-EM), its molecular basis and most importantly, the differences between eukaryotic pathogens and their mammalian hosts.

translation in mammals

mRNA translation in mammals with a particular focus on the structural differences compared to parasites

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translation in parasites

mRNA translation in trypanosomatides and kinetoplastids with a focus on the initiation step and its unique features

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translation in mitochondria

mitochondria mRNA translation in unicellular parasites (e.g. Trypanosomes) and hosts (e.g. plants)

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About the lab

We are part of the ARNA unit (Nucleic Acids: Natural and Artificial Regulation),
Inserm U1212 – CNRS UMR 5320 and we are affiliated the University of Bordeaux.
We are located at the European Institute of Chemistry and Biology (IECB) in the city of Bordeaux, France.

Last Tweets

Yaser Hashem
@Hashemyaser4Jan 28
RT @LugerLab: News alert: Some bacteria have histones y'all. Shawn Laursen from @LugerLab shows how they bind DNA in VERY unexpected way,…
Yaser Hashem
@Hashemyaser4Jan 26
RT @MaxGemmer: Very happy to share our recent work on protein biogenesis at the ER membrane. We analyzed 150,000 ribosomes from 1000+ tomog…
Yaser Hashem
@Hashemyaser4Jan 25
RT @SchullerJm: We are proud to present our latest work on enzymatic decorated protein nanowires. AOR from A. aromaticum is another enzyme…
Yaser Hashem
@Hashemyaser4Jan 21
RT @RubinsteinJohn: Mycobacteria possess a branched and flexible electron transport chain In her review in #BiochemSocTrans, @think_zesty s…
Yaser Hashem
@Hashemyaser4Jan 21
RT @NatureSMB: ❄️our January issue is live❄️ on the cover we feature work from @davidwtaylorjr & @ArlenJohnson8 labs on how a single 2′-O-…
Yaser Hashem
@Hashemyaser4Jan 20
RT @BaretJc: We are hiring ! We have 3 openings in the group: - 1 PhD: active soft matter & plancton - 1 Post-doc: microfluidics and react…
Yaser Hashem
@Hashemyaser4Jan 19
RT @UFScripps: Life literally unfolds before our eyes in day two of #RNAfl2023. Patrick Cramer, PhD, @CramerLab, pres-elect of @maxplanckpr
Yaser Hashem
@Hashemyaser4Jan 19
RT @FriedaLeesch: Our paper on dormant egg ribosomes is out now! I couldn't be more grateful to work with @llorenzoorts,@PauliGroup @Haselb
Yaser Hashem
@Hashemyaser4Jan 09
RT @DoyleMT1: Simply an amazing piece by the Endo, Pfanner, & Wiedemann Labs! First hybrid-barrel structure to be solved on the SAM complex…
Yaser Hashem
@Hashemyaser4Jan 08
RT @hauryliuk: Very intersiting story from @johan_elf_ - Antibiotic perseverance increases the risk of resistance in @PNASNews https://t.co