Welcome to the Hashem Lab

Our research is focused on mRNA translation in eukaryotic pathogens and their hosts. We endeavor to understand the regulation of the translation process and decipher structurally, using CryoEM-electron microscopy (cryo-EM), its molecular basis and most importantly, the differences between eukaryotic pathogens and their mammalian hosts.

translation in mammals

mRNA translation in mammals with a particular focus on the structural differences compared to parasites

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translation in parasites

mRNA translation in trypanosomatides and kinetoplastids with a focus on the initiation step and its unique features

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translation in mitochondria

mRNA translation in mitochondria in both pathogenic parasites and their mammalian hosts

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About the lab

We are part of the ARNA unit (Nucleic Acids: Natural and Artificial Regulation),
Inserm U1212 – CNRS UMR 5320 and we are affiliated the University of Bordeaux.
We are located at the European Institute of Chemistry and Biology (IECB) in the city of Bordeaux, France.

Last Tweets

Yaser Hashem
@Hashemyaser4Oct 21
Beautiful paper bout tRNA modification in position 37 and fidelity of mRNA translation https://t.co/O7iJAGzlUM
Yaser Hashem
@Hashemyaser4Oct 21
RT @loquet_lab: Happy to contribute @JMolBiol to the last study from the Saupe group on #NLR #amyloid #NMR in bacteria with @Brice_Kauffman
Yaser Hashem
@Hashemyaser4Oct 21
@JinfanW The ribosomes of these hosts might present a substantially higher affinity to the Halv IGR IRES. One needs… https://t.co/JpM2OQpkKS
Yaser Hashem
@Hashemyaser4Oct 21
@JinfanW Yes native mRNA and P-site tRNA, some translation factors too... Well it has been discovered in fish, whic… https://t.co/uBQK8ezxgZ
Yaser Hashem
@Hashemyaser4Oct 21
@amy_b_jobe Tiny, and absurdly simple... Thanks!
Yaser Hashem
@Hashemyaser4Oct 21
@JinfanW Thank you Jinfan! not sure how it compares to yeast's ribosome in terms of affinity, similarly to many IGR… https://t.co/w95OSWeMHx
Yaser Hashem
@Hashemyaser4Oct 21
Finally, last but not least, special thanks to the @iecb_bordeaux
Yaser Hashem
@Hashemyaser4Oct 21
@hauryliuk haha certainly 😅
Yaser Hashem
@Hashemyaser4Oct 21
Finally big big thanks to the @BordeauxSts, @univbordeaux, @Inserm and @arna_lab for ongoing support, but also… https://t.co/enXwFyDctz
Yaser Hashem
@Hashemyaser4Oct 21
This collaboration with Tanya and Chris felt like home to me 🤓 Congrats to Irina Abaeva and @qvicens who did all th… https://t.co/UO2RzlOyFY