Hashem Lab
Publications
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The Halastavi árva virus intergenic region IRES promotes translation by the simplest possible initiation mechanism
Abaeva I S, Vicens Q, Bochler A, Soufari H, Simonetti A, Pestova T V, Hashem Y, Hellen C U T (2020). Cell Reports Volume 33, 108476. DOI: 10.1016/j.celrep.2020.108476. (preprint on bioRxiv)
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Specificities of the plant mitochondrial translation apparatus
Waltz F, Corre N, Hashem Y, Giegé P. (2020). Mitochondrion. pii: S1567-7249(20)30013-1. doi: 10.1016/j.mito.2020.04.008.
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Structural Differences in Translation Initiation between Pathogenic Trypanosomatids and Their Mammalian Hosts
Bochler A, Brito Querido J, Prilepskaja T, Soufari H, Lucia Del Cistia M, Kuhn L, Rimoldi Ribeiro A, Valasek LS, Hashem Y. (2020). Cell Reports Volume 33, 108534. DOI: 10.1016/j.celrep.2020.108534. (preprint on bioRxiv)
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Specific features and assembly of the plant mitochondrial complex I revealed by cryo-EM
Soufari H, Parrot C, Kuhn L, Waltz F, Hashem Y. (2020). Nature Communications volume 11, 5195. DOI: 10.1038/s41467-020-18814-w.(preprint on bioRxiv)
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Cryo-EM structure of the RNA-rich plant mitochondrial ribosome
Waltz F, Soufari H, Bochler A, Giegé P, Hashem Y (2020). Nature plants. 6, 377–383. DOI: 10.1038/s41477-020-0631-5. (free preprint on BioRxiv)
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Structural insights into the mammalian late-stage initiation complexes
Simonetti A, Guca E, Bochler A, Kuhn L, Hashem Y (2020). Cell Reports 31, 107497. DOI: https://doi.org/10.1016/j.celrep.2020.03.061. (preprint on BioRxiv)
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Small is big in Arabidopsis mitochondrial ribosome
Waltz F, Nguyen TT, Arrivé M, Bochler A, Chicher J, Hammann P, Kuhn L, Quadrado M, Mireau H, Hashem Y, Giegé P (2019). Nature plants. 5, 106-117. doi: 10.1038/s41477-018-0339-y.
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Major structural rearrangements of the canonical eukaryotic translation initiation complex
Guca E & Hashem Y (2018). Current Opinion in Structural Biology, Issue 53: Protein and nucleic acid interactions, p.151-158.
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Structural insights into the role of diphthamide on elongation factor 2 in mRNA reading-frame maintenance
Pellegino S, Demeshkina N, Mancera-Martinez E, Melnikov S, Simonetti A, Myasnikov A, Yusupov M, Yusupova G, Hashem Y (2018). J Mol Biol 430,2677-2687.
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The jigsaw puzzle of mRNA translation initiation in eukaryotes: a decade of structures unraveling the mechanics of the process
Hashem Y, Frank J (2018). Annual review of biophysics 47, 125-151
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The cryo-EM Structure of a Novel 40S Kinetoplastid-Specific Ribosomal Protein
Querido JB, Mancera-Martínez E, Vicens Q, Bochler A, Chicher J, Simonetti A, Hashem Y (2017). Structure 25 (12), 1785-1794. e3
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ABCE1: A special factor that orchestrates translation at the crossroad between recycling and initiation
Mancera-Martínez E, Querido JB, Valasek LS, Simonetti A, Hashem Y (2017). RNA biology 14 (10), 1279-1285
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Structures and dynamics of hibernating ribosome’s from Staphylococcus aureus mediated by intermolecular interactions of HPF
Khusainov I, Vicens Q, Ayupov R, Usachev K, Myasnikov A, Simonetti A, Validov S, Kieffer B, Yusupova G, Yusupov M, Hashem Y (2017). EMBO J 36,2073-2087.
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Structure of the 70S ribosome from human pathogen Staphylococcus aureus
Khusainov I, Vicens Q, Bochler A, Grosse F, Myasnikov A, Ménétret JF, Chicher J, Marzi S, Romby P, Yusupova G, Yusupov M, Hashem Y (2017). Nucleic Acids Res 45,1026.
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Embraced by eIF3: structural and functional insights into the roles of eIF3 across the translation cycle
Valasek LS, Zeman J, Wagner S, Beznoskova P, Pavlíkova Z, Mohammad MP, Hronova V, Herrmannova A, Hashem Y, Gunisova S (2017). Nucleic Acids Res 45,10948-10968.
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A glimpse on Staphylococcus aureus translation machinery and its control
Khusainov I, Marenna A, Cerciat M, Fechter P, Hashem Y, Marzi S, Romby P, Yusupova G, Yusupov M (2016). Molecular Biology, 50:477-488.
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eIF3 peripheral subunits rearrangement after mRNA binding and start-codon recognition
Simonetti A, Querido JB, Myasnikov AG, Mancera-Martinez E, Renaud A, Kuhn L, Hashem Y (2016). Molecular Cell 63 (2), 206-217
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pseudouridylation switch in rRNA is implicated in ribosome function during the life cycle of Trypanosoma brucei
Chikne V, Doniger T, Rajan KS, Bartok O, Eliaz D, Cohen-Chalamish S, Tschudi C, Unger R, Hashem Y, Kadener S, Michaeli SA (2016). Scientific Reports 6: Article number: 25296.
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Dynamical features of the Plasmodium falciparum ribosome during translation.
Sun M, Li W, Blomqvist K, Das S, Hashem Y, Dvorin JD, Frank J (2015). Nucleic Acids Res 43:10515-10524.
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Structure of mammalian eIF3 in the context of the 43S preinitiation complex
des Georges A, Dhote V, Kuhn L, Hellen CUT, Pestova TV, Frank J, Hashem Y (2015). Nature 525,491–495.
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Efficient estimation of three-dimensional covariance and its application in the analysis of heterogeneous samples in cryo-electron microscopy
Liao HY, Hashem Y, Frank J (2015). Structure 23:1129-37.
Y. H. Postdoc publications:
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EttA binds at ribosomal E site and regulates translation by restricting ribosome dynamics
Chen B, Boël G, Hashem Y, Ning W, Fei J, Wang C, Gonzalez RL Jr., Hunt JF, Frank J (2014). NSMB doi:10.1038/nsmb.2741.
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EttA, an energy-sensing ABC-F protein, gates ribosome entry into the elongation cycle
Boël G, Smith PC, Englander MT, Chen B, Hashem Y, Testa AJ, Fischer JJ, Wieden HJ, Frank J, Gonzalez RL Jr., Hunt JF (2014). NSMB doi:10.1038/nsmb.2740.
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Structure of the mammalian ribosomal pre-termination complex associated with eRF1•eRF3•GDPNP
des Georges A, Hashem Y, Unbehau A, Grassucci RA, Taylor D, Hellen CUT, Pestova TV, Frank J (2013). Nucleic Acides Res 42:3409–3418.
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Hepatitis-C-virus-like internal ribosome entry sites displace eIF3 to gain access to the 40S subunit
Hashem Y, Des Georges A, Dhote V, Langlois R, Liao YH, Grassucci RA, Pestova TV, Hellen CUT, Frank J (2013). Nature 503:539-543.
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RF3 action is regulated by a class-I release factor and L7/L12 during translation termination
Pallesen J, Hashem Y, Koripella RV, Korkmaz G, Huang C, Ehrenberg M, Sanyal S, Frank J (2013;2). eLife:e00411.
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Structural insight into the mammalian ribosomal 43S preinitiation complex
Hashem Y, Des Georges A, Dhote V, Langlois R, Liao YH, Grassucci RA, Hellen CUT, Pestova TV, Frank J (2013). Cell 153:1108-1119.
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High-resolution cryo-EM structure of the Trypanosoma bruceieukaryotic ribosome
Hashem Y, Des Georges A, Fu J, Buss SN, Jossinet F, Jobe A, Zhang Q, Liao HY, Grassucci RA, Bajaj C, Westhof E, Madison-Antenucci S, Frank J (2013). Nature 494:385–389.
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Integrity of the P-site is probed during maturation of the 60S ribosomal subunit
Bussiere C, Hashem Y, Arora S, Frank J, Johnson AW (2012). JCB 197:747-59.
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tmRNA on its way through the ribosome: Two steps of resume, and what next?
Fu J, Hashem Y, Wower J, Frank J (2011). RNA Biol 1;8:586-90.
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Visualizing the transfer-messenger RNA as the ribosome resumes translation