THE HASHEM LAB

New papers
Cryo-EM structure of the RNA-rich plant mitochondrial ribosome (2020). Nature plants

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New papers
N6-methyladenosine in 5′ UTR does not promote translation
initiation (2024). Molecular Cell

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New papers
Regulation of the macrolide resistance ABC-F translation factor MsrD (2023). Nature Communications

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New papers
How to build a ribosome from RNA fragments in Chlamydomonas mitochondria (2021). Nature Communications

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New papers
Structural differences in translation initiation between pathogenic trypanosomatids and their mammalian hosts (2020). Cell Reports

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BIOPHYSICS WEEK EBSA LECTURE
Single particle cryo-electron microscopy: A method of choice for solving large and heterogeneous molecular complexes
Dr. Yaser Hashem, Université de Bordeaux, EBSA Young Investigator Award 2021

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Welcome to the Hashem Lab

Our research is focused on mRNA translation in eukaryotic pathogens and their hosts. We endeavor to understand the regulation of the translation process and decipher structurally, using CryoEM-electron microscopy (cryo-EM), its molecular basis and most importantly, the differences between eukaryotic pathogens and their mammalian hosts.

translation in mammals

mRNA translation in mammals with a particular focus on the structural differences compared to parasites

translation in parasites

mRNA translation in trypanosomatides and kinetoplastids with a focus on the initiation step and its unique features

translation in mitochondria

mitochondria mRNA translation in unicellular parasites (e.g. Trypanosomes) and hosts (e.g. plants)

We are part of the ARNA unit (Nucleic Acids: Natural and Artificial Regulation),
Inserm U1212 – CNRS UMR 5320 and we are affiliated the University of Bordeaux.

We are located at the European Institute of Chemistry and Biology (IECB) in the city of Bordeaux, France.

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